Metal-free (Boc)2O-mediated C4-selective direct indolation of pyridines using TEMPO.
نویسندگان
چکیده
Direct metal-free C-4-selective indolation of pyridines is achieved for the first time using TEMPO and (Boc)2O. A variety of substituents on both indoles and pyridines are tolerated to give 3-(pyridin-4-yl)-1H-indole derivatives in moderate to excellent yields. This finding provides a novel approach for developing metal-free C-H functionalization of pyridines.
منابع مشابه
Transition-Metal-Catalyzed C–H Functionalization for the Synthesis of Substituted Pyridines Transition-Metal-Catalyzed C–H Functionalization
SYNTHESIS 2011, No. 20, pp 3209–3219xx.xx.2011 Advanced online publication: 07.09.2011 DOI: 10.1055/s-0030-1260212; Art ID: E69311SS © Georg Thieme Verlag Stuttgart · New York Abstract: The direct functionalization of pyridine and related azine derivatives through carbon–carbon bond-forming reactions is reviewed. Various transformations that use a variety of transitionmetal catalysts are covere...
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 12 24 شماره
صفحات -
تاریخ انتشار 2014